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Description
Membranous nephropathy is a disease in which the small blood vessels in the kidney (glomerulus) becomes inflamed and thickened. As a result, proteins to leak from the blood vessels are broken into urine (proteinuria,).
For many people, the loss of this protein has finally caused some signs and symptoms known as syndrome nefrotik.
In the case of light, these diseases often get better by itself, although without treatment. In many people, the disease eventually lead to kidney failure. Although there is a cure, treatments are available to slow down the progression of the disease only.
The Cause Of
To date, the cause of most cases of membranous nephropathy is unknown, so it is called idiopathic. But new research has found evidence of autoimmune activity in majority of the cases studied.
In autoimmune diseases, such as rheumatoid arthritis or lupus, the immune system mistakes, as foreign invaders and attack with autoantibodi.
Autoantibodi is considered as the cause of damage to the glomeruli in most cases of membranous nephropathy. Sometimes the membranous nephropathy is carried by other causes, in particular:
1. infection of hepatitis B and C
2. certain medicines
3. Tumor
Symptoms
Membranous nephropathy usually develops gradually, so people often do not see anything wrong. When lose more protein from the blood, maybe be visible swelling in legs and ankles due to excess fluid. Many people also may experience swelling of the beginning of the disease.
Most people do not have symptoms of kidney disease until their weight already up. Signs and symptoms can include:
1. swelling of the feet and ankles
2. Fatigue
3. diminishing appetite
4. Difficult to sleep
5. Increased urination, especially at night
6. blood clotting
7. Infection
8. foaming Urine
Treatment
Treatment focuses on addressing the causes of diseases and relieve symptoms. In cases where the disease is caused by medication or other illnesses like tumours, stop the remedy or control other diseases will usually improve the patient's condition.
Generally, the first step to control the loss of protein by the kidneys is a conservative treatment. The therapy consists of:
1. Control blood pressure with the help of medicines which inhibit angiotensin II system, such as angiotensin converting enzyme (ACE) inhibitors.
2. Reduce swelling (edema) with a water pill (diuretic), which helps release sodium and water from the blood.
3. control your cholesterol levels with the help of statin drugs.
4. reduce the amount of protein in the diet.
